We studied 30 patients (22 males mean±sd age 49.9☑3.5 years) 3-15 days from symptom onset and again during recovery, 55☑0 days later (n=17). We aimed to measure shunt and alveolar dead space in moderate COVID-19 during acute illness and recovery. We propose that measuring respiratory gas exchange enables detection and quantification of these abnormalities. Pathological evidence suggests that coronavirus disease 2019 (COVID-19) pulmonary infection involves both alveolar damage (causing shunt) and diffuse microvascular thrombus formation (causing alveolar dead space).
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